ea0028p164 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012
Fenech Matthew
, Swingler Tracey
, Gavrilovic Jelena
, Sampson Mike
, Turner Jeremy
The development of insulin resistance and type 2 diabetes mellitus (T2DM) in obesity involves (a) adipose inflammation, and (b) restricted adipose expansion with ectopic lipid deposition. Metalloproteinases (MPs) and tissue inhibitors of metalloproteinases (TIMPs) constitute a key regulatory system in inflammation and tissue remodelling. Evidence of MP and TIMP involvement in adipose tissue inflammation and modulation of adipose expansion is currently restricted to work in adi...